Paper Info
Title
Improved SPECT reconstruction of Tc-99m sestamibi distribution in breast tissue
Abstract
This paper describes a new image reconstruction method to reduce the presence of image artifacts in scintimammography. SPECT data are mathematically modified prior to conventional image processing, followed by an inverse transform, which permits the tomographic visualization of low signals in the presence of large background intensities observed in scintimammography. Images of Tc-99m sestamibi distribution were obtained in a modeled "breast tissue", with a high activity in the "myocardium" as compared to the "breast tissue" (i.e. 20:1). Image reconstruction with the modified algorithm were qualitatively correct and demonstrated the regions of enhanced uptake (lesions) with no evidence of artifacts from the background counts in the heart. Comparison with MRI demonstrated that the hot regions were properly located and correlated with the MRI data. In contrast, a standard (i.e. Filtered Back Projection) reconstruction resulted in streak artifacts in place of "breast tissue" which rendered them clinically useless. This new approach to scintimammography offers the prospect of significantly reducing image artifacts and improving imaging accuracy.
Year
DOI
Venue
1998
10.1117/12.310923
PROCEEDINGS OF THE SOCIETY OF PHOTO-OPTICAL INSTRUMENTATION ENGINEERS (SPIE)
Keywords
Field
DocType
breast-radionuclide studies,SPECT reconstruction
Iterative reconstruction,Single-photon emission computed tomography,Nuclear medicine,Technetium (99mTc) sestamibi,Scintimammography,Computer science,Streak,Image processing,Image restoration,Radon transform
Conference
Volume
ISSN
Citations 
3338
0277-786X
0
PageRank 
References 
Authors
0.34
0
7
Name
Order
Citations
PageRank
Andrzej Krol1298.49
David H. Feiglin2188.32
g m gagne300.34
walter huda401.01
gwen m tillapoughfay500.34
bradford j hellwig600.34
deaver f thomas700.34