Paper Info
Title
Quantitative assessment of smoking-induced emphysema progression in longitudinal CT screening for lung cancer
Abstract
Computed tomography has been used for assessing structural abnormalities associated with emphysema. It is important to develop a robust CT based imaging biomarker that would allow quantification of emphysema progression in early stage. This paper presents effect of smoking on emphysema progression using annual changes of low attenuation volume (LAV) by each lung lobe acquired from low-dose CT images in longitudinal screening for lung cancer. The percentage of LAV (LAV%) was measured after applying CT value threshold method and small noise reduction. Progression of emphysema was assessed by statistical analysis of the annual changes represented by linear regression of LAV%. This method was applied to 215 participants in lung cancer CT screening for five years (18 nonsmokers, 85 past smokers, and 112 current smokers). The results showed that LAV% is useful to classify current smokers with rapid progression of emphysema (0.2%/year, p<0.05). This paper demonstrates effectiveness of the proposed method in diagnosis and prognosis of early emphysema in CT screening for lung cancer.
Year
DOI
Venue
2015
10.1117/12.2082054
Proceedings of SPIE
Keywords
Field
DocType
emphysema,low dose CT screening,3D image analysis
Lung cancer,Computer vision,Lung,Imaging biomarker,Computed tomography,Artificial intelligence,Quantitative assessment,Radiology,Medical diagnostics,Physics,Statistical analysis
Conference
Volume
ISSN
Citations 
9414
0277-786X
0
PageRank 
References 
Authors
0.34
1
12
Name
Order
Citations
PageRank
hiroyuki suzuki100.34
r mizuguchi200.34
mikio matsuhiro354.05
Yoshiki Kawata419254.44
Noboru Niki518866.10
yasutaka nakano611.81
Hironobu Ohmatsu713845.23
masahiko kusumoto84616.28
takaaki tsuchida904.39
Kenji Eguchi1012942.78
mika kato kaneko1100.34
Noriyuki Moriyama1214850.47