Title
Computational modeling suggests distinct, location-specific function of norepinephrine in olfactory bulb and piriform cortex.
Abstract
Noradrenergic modulation from the locus coerulus is often associated with the regulation of sensory signal-to-noise ratio. In the olfactory system, noradrenergic modulation affects both bulbar and cortical processing, and has been shown to modulate the detection of low concentration stimuli. We here implemented a computational model of the olfactory bulb and piriform cortex, based on known experimental results, to explore how noradrenergic modulation in the olfactory bulb and piriform cortex interact to regulate odor processing. We show that as predicted by behavioral experiments in our lab, norepinephrine can play a critical role in modulating the detection and associative learning of very low odor concentrations. Our simulations show that bulbar norepinephrine serves to pre-process odor representations to facilitate cortical learning, but not recall. We observe the typical non-uniform dose response functions described for norepinephrine modulation and show that these are imposed mainly by bulbar, but not cortical processing.
Year
DOI
Venue
2015
10.3389/fncom.2015.00073
FRONTIERS IN COMPUTATIONAL NEUROSCIENCE
Keywords
Field
DocType
noradrenaline,olfactory bulb,piriform cortex,odor detection,odor learning,odor recall
Olfactory bulb,Olfactory memory,Neuroscience,Olfactory system,Odor,Computer science,Stimulus (physiology),Associative learning,Sensory system,Piriform cortex
Journal
Volume
ISSN
Citations 
9
1662-5188
0
PageRank 
References 
Authors
0.34
0
4
Name
Order
Citations
PageRank
licurgo de almeida100.34
seungdo j reiner200.34
matthew ennis300.34
Christiane Linster46630.43