Paper Info
Title
Optimizing the delivery of deep brain stimulation using electrophysiological atlases and an inverse modeling approach
Abstract
The use of deep brain stimulation (DBS) for the treatment of neurological movement degenerative disorders requires the precise placement of the stimulating electrode and the determination of optimal stimulation parameters that maximize symptom relief (e. g. tremor, rigidity, movement difficulties, etc.) while minimizing undesired physiological side-effects. This study demonstrates the feasibility of determining the ideal electrode placement and stimulation current amplitude by performing a patient-specific multivariate optimization using electrophysiological atlases and a bioelectric finite element model of the brain. Using one clinical case as a preliminary test, the optimization routine is able to find the most efficacious electrode location while avoiding the high side-effect regions. Future work involves optimization validation clinically and improvement to the accuracy of the model.
Year
DOI
Venue
2012
10.1117/12.912024
Proceedings of SPIE
Keywords
Field
DocType
Deep brain stimulation,finite element modeling,optimization
Rigidity (psychology),Biomedical engineering,Inverse,Computer vision,Deep brain stimulation,Electrode location,Finite element method,Current amplitude,Artificial intelligence,Electrophysiology,Stimulation,Physics
Conference
Volume
ISSN
Citations 
8316
0277-786X
0
PageRank 
References 
Authors
0.34
0
6
Name
Order
Citations
PageRank
Kay Sun1133.21
Srivatsan Pallavaram2699.45
william rodriguez331.08
Pierre-françois D'haese4437.54
Benoit M. Dawant51388223.11
Michael I. Miga656772.99