Paper Info
Title
Modeling and control of pharmacodynamics
Abstract
Modeling and control of drug dosing regimes are particularly well-suited for applications of control design and analysis techniques. These problems frequently incorporate the use of mathematical models, lending themselves to a large range of model-based control methods. There has been ongoing research aimed at the development of closed-loop drug dosing and delivery regimens in a number of specific medical domains for more than five decades. In this paper, we discuss the development of modeling and control methods aimed at closed-loop delivery of pharmaceutical agents. We focus most of this discussion on the problem of controlling sedation levels during surgical procedures; results from the application of linear parameter varying and robust L1-adaptive modeling and control approaches are presented in some detail.
Year
DOI
Venue
2015
10.1016/j.ejcon.2015.04.006
European Journal of Control
Keywords
Field
DocType
Pharmacokinetics,Pharmacodynamics,Anesthesia control piecewise-linear systems,Linear parameter varying control,Robust and adaptive control
Control theory,Linear parameter-varying control,Control engineering,Pharmacodynamics,Mathematical model,Dosing,Mathematics
Journal
Volume
ISSN
Citations 
24
0947-3580
2
PageRank 
References 
Authors
0.45
18
1
Name
Order
Citations
PageRank
Carolyn L. Beck140160.19