Title
Multicore and GPU algorithms for Nussinov RNA folding
Abstract
One segment of a RNA sequence might be paired with another segment of the same RNA sequence due to the force of hydrogen bonds. This two-dimensional structure is called the RNA sequence's secondary structure. Several algorithms have been proposed to predict an RNA sequence's secondary structure. These algorithms are referred to as RNA folding algorithms.We develop cache efficient, multicore, and GPU algorithms for RNA folding using Nussinov's algorithm.Our cache efficient algorithm provides a speedup between 1.6 and 3.0 relative to a naive straightforward single core code. The multicore version of the cache efficient single core algorithm provides a speedup, relative to the naive single core algorithm, between 7.5 and 14.0 on a 6 core hyperthreaded CPU. Our GPU algorithm for the NVIDIA C2050 is up to 1582 times as fast as the naive single core algorithm and between 5.1 and 11.2 times as fast as the fastest previously known GPU algorithm for Nussinov RNA folding.
Year
DOI
Venue
2014
10.1186/1471-2105-15-S8-S1
BMC Bioinformatics
Keywords
Field
DocType
microarrays,algorithms,bioinformatics
RNA,RNA Sequence,Computer science,Rna folding,Algorithm,Bioinformatics,Protein secondary structure,Multi-core processor,DNA microarray
Journal
Volume
Issue
ISSN
15
S8
1471-2105
Citations 
PageRank 
References 
3
0.43
9
Authors
3
Name
Order
Citations
PageRank
Junjie Li13012.76
Sanjay Ranka22017303.99
Sartaj Sahni363161764.85