Paper Info
Title
ProViz-a web-based visualization tool to investigate the functional and evolutionary features of protein sequences.
Abstract
Low-throughput experiments and high-throughput proteomic and genomic analyses have created enormous quantities of data that can be used to explore protein function and evolution. The ability to consolidate these data into an informative and intuitive format is vital to our capacity to comprehend these distinct but complementary sources of information. However, existing tools to visualize protein-related data are restricted by their presentation, sources of information, functionality or accessibility. We introduce ProViz, a powerful browser-based tool to aid biologists in building hypotheses and designing experiments by simplifying the analysis of functional and evolutionary features of proteins. Feature information is retrieved in an automated manner from resources describing protein modular architecture, post-translational modification, structure, sequence variation and experimental characterization of functional regions. These features are mapped to evolutionary information from precomputed multiple sequence alignments. Data are displayed in an interactive and information-rich yet intuitive visualization, accessible through a simple protein search interface. This allows users with limited bioinformatic skills to rapidly access data pertinent to their research. Visualizations can be further customized with user-defined data either manually or using a REST API. ProViz is available at http://proviz.ucd.ie/.
Year
DOI
Venue
2016
10.1093/nar/gkw265
NUCLEIC ACIDS RESEARCH
Field
DocType
Volume
Web based visualization,Sequence alignment,Information retrieval,Biology,Visualization,Datasets as Topic,Bioinformatics,Genetics,Computer graphics,Modular architecture,Evolutionary information,The Internet
Journal
44
Issue
ISSN
Citations 
W1
0305-1048
4
PageRank 
References 
Authors
0.41
19
5
Name
Order
Citations
PageRank
Peter Jehl1492.73
Jean Manguy250.77
Denis C. Shields315820.92
Desmond G. Higgins4151.60
Norman E. Davey522816.61