Title | ||
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Semiparametric regression analysis of panel count data allowing for within-subject correlation |
Abstract | ||
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In this paper, a maximum likelihood approach is proposed for analyzing panel count data under the gamma frailty non-homogeneous Poisson process model. The approach allows one to estimate the baseline mean function and the regression parameters jointly while taking the within-subject correlation into account. The within-subject correlation is quantified explicitly by Pearson's correlation coefficient. Monotone splines are adopted to approximate the unspecified nondecreasing baseline mean function in the model. An expectation-maximization (EM) algorithm is derived to facilitate the computation by exploiting a data augmentation based on Poisson latent variables. The EM algorithm is robust to initial values, easy to implement, converges fast, and provides closed-form variance estimates. It can be also applied to the non-homogeneous Poisson model without frailty. The proposed approach is evaluated through simulations and illustrated by two real-life examples coming from a skin cancer study and a bladder tumor study. A companion R package PCDSpline has been developed and is available on R CRAN for public use. |
Year | DOI | Venue |
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2016 | 10.1016/j.csda.2015.11.017 | Computational Statistics & Data Analysis |
Keywords | Field | DocType |
EM algorithm,Gamma frailty,Monotone splines,Panel count data,Poisson process | Econometrics,Correlation coefficient,Regression,Expectation–maximization algorithm,Latent variable,Count data,Poisson regression,Semiparametric regression,Poisson distribution,Statistics,Mathematics | Journal |
Volume | Issue | ISSN |
97 | C | 0167-9473 |
Citations | PageRank | References |
0 | 0.34 | 3 |
Authors | ||
3 |
Name | Order | Citations | PageRank |
---|---|---|---|
Bin Yao | 1 | 0 | 0.34 |
Lianming Wang | 2 | 13 | 4.49 |
Xin He | 3 | 2 | 1.19 |