Name
Abstract | ||
|---|---|---|
Isotope labeling experiments (ILEs) are increasingly used to investigate the functioning of metabolic systems. Some enzymes are subject to kinetic isotope effects (KIEs) which modulate reaction rates depending on the isotopic composition of their substrate(s). KIEs may therefore affect both the propagation of isotopes through metabolic networks and their operation, and ultimately jeopardize the biological value of ILEs. However, the actual impact of KIEs on metabolism has never been investigated at the system level. |
Year | DOI | Venue |
|---|---|---|
2015 | 10.1186/s12918-015-0213-8 | BMC Systems Biology |
Keywords | Field | DocType |
Isotope effect, Isotope labeling experiment, Metabolic flux analysis, Fluxomics, Kinetic model, Isotopic model | Isotopes of carbon,Biology,Biochemistry,Fluxomics,Isotope,Metabolic flux analysis,Environmental chemistry,Cell biology,Kinetic model,Kinetic isotope effect,System level | Journal |
Volume | Issue | ISSN |
9 | 1 | 1752-0509 |
Citations | PageRank | References |
1 | 0.37 | 2 |
Authors | ||
3 | ||
Name | Order | Citations | PageRank |
|---|---|---|---|
| Pierre Millard | 1 | 13 | 3.05 |
| Jean-Charles Portais | 2 | 15 | 3.25 |
| Pedro Mendes | 3 | 648 | 51.61 |