Title
Multiplane spectroscopic whole-body photoacoustic imaging of small animals in vivo.
Abstract
We have successfully developed a multiscale acoustic-resolution photoacoustic tomography system in a single imaging platform. By switching between ultrasound transducers (center frequencies 5 and 40 MHz) and optical condensers, we have photoacoustically imaged microvasculatures of small animals in vivo at different scales. Further, we have extended the field of view of our imaging system to entire bodies of small animals. At different imaging planes, we have noninvasively imaged the major blood vessels (e.g., descending aorta, intercostal vessels, cephalic vessels, brachial vessels, femoral vessels, popliteal vessels, lateral marginal vessels, cranial mesenteric vessels, mammalian vessels, carotid artery, jugular vein, subclavian vessels, iliac vessels, and caudal vessels) as well as intact internal organs (e.g., spleen, liver, kidney, intestine, cecum, and spinal cord) of the animals in vivo. The spectroscopic whole-body photoacoustic imaging clearly reveals the spectral responses of the internal structures. Similar to other existing preclinical whole-body imaging systems, this whole-body photoacoustic tomography can be a useful tool for small-animal research.
Year
DOI
Venue
2016
10.1007/s11517-014-1182-6
Medical & biological engineering & computing
Keywords
Field
DocType
Photoacoustic imaging, Multiscale imaging, Whole-body imaging, Small-animal imaging
Jugular vein,Spinal cord,Anatomy,Iliac vessels,Photoacoustic imaging in biomedicine,Descending aorta,In vivo,Whole body imaging,Mathematics,Ultrasound
Journal
Volume
Issue
ISSN
54
2-3
1741-0444
Citations 
PageRank 
References 
2
0.66
2
Authors
3
Name
Order
Citations
PageRank
Mansik Jeon156.12
Jeesu Kim232.43
Chulhong Kim3869.30