Name
Title | ||
|---|---|---|
Trial-by-trial relationship between neural activity, oxygen consumption, and blood flow responses |
Abstract | ||
|---|---|---|
Trial-by-trial variability in local field potential (LFP), tissue partial pressure of oxygen (PO2), cerebral blood flow (CBF), and deoxyhemoglobin-weighted optical imaging of intrinsic signals (OIS) were tested in the rat somatosensory cortex while fixed electrical forepaw stimulation (1.0-ms pulses with amplitude of 1.2 mA at a frequency of 6 Hz) was repeatedly applied. The changes in the cerebral metabolic rate of oxygen (CMRO2) were also evaluated using a hypotension condition established by our group based on the administration of a vasodilator. Under normal conditions, CBF, PO2, and OIS showed positive signal changes (48%, 32%, and 0.42%, respectively) following stimulation. Over multiple trials, the CBF responses were well correlated with the integral of the LFP amplitudes (∑LFP) (Rmean=0.78), whereas a lower correlation was found between PO2 and ∑LFP (Rmean=0.60) and between OIS and ∑LFP (Rmean=0.54). Under the hypotension condition the LFP responses were preserved, but the CBF responses were suppressed and the PO2 and OIS changes were negative (−12% and −0.28%, respectively). In this condition, the trial-by-trial variations in PO2 and OIS were well correlated with the variability in ∑LFPs (Rmean=−0.77 and −0.76, respectively), indicating a single trial coupling between CMRO2 changes and ∑LFP. These findings show that CBF and CMRO2 signals are more directly correlated with neural activity compared to blood oxygen-sensitive methods such as OIS and BOLD fMRI. |
Year | DOI | Venue |
|---|---|---|
2008 | 10.1016/j.neuroimage.2007.12.011 | NeuroImage |
Keywords | Field | DocType |
fMRI,Neurometabolic coupling,Neurovascular coupling | Oxygen,Anesthesia,Cognitive psychology,Neural activity,Somatosensory system,Vasodilation,Stimulation,Blood flow,Internal medicine,Cardiology,Psychology,Cerebral blood flow,Local field potential | Journal |
Volume | Issue | ISSN |
40 | 2 | 1053-8119 |
Citations | PageRank | References |
7 | 0.75 | 1 |
Authors | ||
4 | ||
Name | Order | Citations | PageRank |
|---|---|---|---|
| Kazuto Masamoto | 1 | 14 | 1.69 |
| Alberto Vazquez | 2 | 74 | 10.23 |
| Ping Wang | 3 | 7 | 0.75 |
| Seong-Gi Kim | 4 | 403 | 55.43 |