Name
Title | ||
|---|---|---|
Heritability of head motion during resting state functional MRI in 462 healthy twins. |
Abstract | ||
|---|---|---|
Head motion (HM) is a critical confounding factor in functional MRI. Here we investigate whether HM during resting state functional MRI (RS-fMRI) is influenced by genetic factors in a sample of 462 twins (65% female; 101 MZ (monozygotic) and 130 DZ (dizygotic) twin pairs; mean age: 21 (SD=3.16), range 16–29). Heritability estimates for three HM components—mean translation (MT), maximum translation (MAXT) and mean rotation (MR)—ranged from 37 to 51%. We detected a significant common genetic influence on HM variability, with about two-thirds (genetic correlations range 0.76–1.00) of the variance shared between MR, MT and MAXT. A composite metric (HM-PC1), which aggregated these three, was also moderately heritable (h2=42%). Using a sub-sample (N=35) of the twins we confirmed that mean and maximum translational and rotational motions were consistent “traits” over repeated scans (r=0.53–0.59); reliability was even higher for the composite metric (r=0.66). In addition, phenotypic and cross-trait cross-twin correlations between HM and resting state functional connectivities (RS-FCs) with Brodmann areas (BA) 44 and 45, in which RS-FCs were found to be moderately heritable (BA44: h2¯=0.23 (sd=0.041), BA45: h2¯=0.26 (sd=0.061)), indicated that HM might not represent a major bias in genetic studies using FCs. Even so, the HM effect on FC was not completely eliminated after regression. HM may be a valuable endophenotype whose relationship with brain disorders remains to be elucidated. |
Year | DOI | Venue |
|---|---|---|
2014 | 10.1016/j.neuroimage.2014.08.010 | NeuroImage |
Keywords | Field | DocType |
HM,MT,MAXT,MR,NUMO,FC,RS,BA,MZ,DZ,ICC,IFC,MFC,SMA,IPC,SPC,ITC,MTC,OC | Heritability,Confounding,Regression,Endophenotype,Resting state fMRI,Broca's area,Psychology,Twin study,Nuclear magnetic resonance | Journal |
Volume | ISSN | Citations |
102 | 1053-8119 | 5 |
PageRank | References | Authors |
0.47 | 16 | 8 |
Name | Order | Citations | PageRank |
|---|---|---|---|
| Baptiste Couvy-Duchesne | 1 | 5 | 0.47 |
| Gabriëlla A M Blokland | 2 | 5 | 0.47 |
| Ian Hickie | 3 | 57 | 4.95 |
| Paul M Thompson | 4 | 190 | 15.64 |
| Nicholas G. Martin | 5 | 16 | 2.98 |
| Greig I. de Zubicaray | 6 | 16 | 2.84 |
| katie l mcmahon | 7 | 36 | 5.26 |
| Margaret J Wright | 8 | 35 | 4.14 |