Name
Title | ||
|---|---|---|
Detection and scaling of task-induced fMRI-BOLD response using resting state fluctuations |
Abstract | ||
|---|---|---|
This study evaluated a calibration technique for scaling the fMRI-BOLD response during a simple motor task. A novel scaling parameter, resting state physiological fluctuation amplitude (RSFA), was tested using previously established scaling factors such as breath hold or 5% CO2. RSFA was hypothesized to contain vascular reactivity information present in the resting state fMRI signal. Subjects were scanned under various stimulus conditions: (a) rest while breathing room air, (b) bilateral fingertapping, (c) breath holding and (d) moderate hypercapnia (breathing 5% CO2+air). In all subjects who breathed 5% CO2, RSFA correlated highly with the BOLD response amplitude during 5% CO2 inhalation. Also, RSFA correlated highly with the amplitude of the BOLD response elicited by breath hold. RSFA was therefore used as a hemodynamic scaling factor to calibrate both the amplitude and spatial extent of the fMRI-BOLD response during the motor task (fingertapping). Results revealed that amplitude scaling using RSFA was similar to that using breath hold or 5% CO2, where the spatial extent of activation diminished by 20–37% over all subjects. Spatial extent of activation changed significantly after scaling and only 30–40% of the activated area overlapped with the unscaled activation. RSFA-scaled task-induced fMRI-BOLD response in both amplitude and spatial extent was comparable to that obtained using breath hold or 5% CO2. We conclude that RSFA may be used to hemodynamically scale the fMRI-BOLD response and does not require the use of a hypercapnic challenge (which may not be purely non-neural), which can be difficult to implement in special populations. |
Year | DOI | Venue |
|---|---|---|
2008 | 10.1016/j.neuroimage.2007.09.040 | NeuroImage |
Keywords | Field | DocType |
fMRI,Breath hold,CO2,CBF,Hypercapnia,Motor cortex,BOLD,Scaling,Hemodynamic | Hemodynamics,Control theory,Resting state fMRI,Psychology,Cognitive psychology,Hypercapnia,Breathing,Motor cortex,Stimulus (physiology),Nuclear magnetic resonance,Scaling,Amplitude | Journal |
Volume | Issue | ISSN |
40 | 4 | 1053-8119 |
Citations | PageRank | References |
30 | 1.84 | 6 |
Authors | ||
2 | ||
Name | Order | Citations | PageRank |
|---|---|---|---|
| Sridhar S. Kannurpatti | 1 | 51 | 4.42 |
| Bharat B. Biswal | 2 | 51 | 4.08 |