Title
The brain's resting-state activity is shaped by synchronized cross-frequency coupling of neural oscillations.
Abstract
Functional imaging of the resting brain consistently reveals broad motifs of correlated blood oxygen level dependent (BOLD) activity that engages cerebral regions from distinct functional systems. Yet, the neurophysiological processes underlying these organized, large-scale fluctuations remain to be uncovered. Using magnetoencephalography (MEG) imaging during rest in 12 healthy subjects we analyze the resting state networks and their underlying neurophysiology. We first demonstrate non-invasively that cortical occurrences of high-frequency oscillatory activity are conditioned to the phase of slower spontaneous fluctuations in neural ensembles. We further show that resting-state networks emerge from synchronized phase–amplitude coupling across the brain. Overall, these findings suggest a unified principle of local-to-global neural signaling for long-range brain communication.
Year
DOI
Venue
2015
10.1016/j.neuroimage.2015.01.054
NeuroImage
Keywords
Field
DocType
Resting state,Phase–amplitude coupling,Neural dynamics,Neural networks and communication
Brain mapping,Neuroscience,Neurophysiology,Nerve net,Blood-oxygen-level dependent,Resting state fMRI,Psychology,Functional imaging,Cerebral cortex,Magnetoencephalography
Journal
Volume
ISSN
Citations 
111
1053-8119
20
PageRank 
References 
Authors
0.96
5
2
Name
Order
Citations
PageRank
Esther Florin1655.93
Baillet, S.237044.42