Title
Challenges in the reproducibility of clinical studies with resting state fMRI: An example in early Parkinson's disease.
Abstract
Resting state fMRI (rfMRI) is gaining in popularity, being easy to acquire and with promising clinical applications. However, rfMRI studies, especially those involving clinical groups, still lack reproducibility, largely due to the different analysis settings. This is particularly important for the development of imaging biomarkers. The aim of this work was to evaluate the reproducibility of our recent study regarding the functional connectivity of the basal ganglia network in early Parkinson's disease (PD) (Szewczyk-Krolikowski et al., 2014). In particular, we systematically analysed the influence of two rfMRI analysis steps on the results: the individual cleaning (artefact removal) of fMRI data and the choice of the set of independent components (template) used for dual regression.
Year
DOI
Venue
2016
10.1016/j.neuroimage.2015.09.021
NeuroImage
Keywords
Field
DocType
Resting state functional magnetic resonance imaging (rfMRI),Functional connectivity,Artefact removal,Dual regression,Basal ganglia network,Parkinson's disease
Brain mapping,Developmental psychology,Reproducibility,Cognitive neuroscience,Neuroscience,Regression,Regression analysis,Resting state fMRI,Neurology,Psychology,Biomarker (medicine)
Journal
Volume
Issue
ISSN
124
Pt A
1053-8119
Citations 
PageRank 
References 
5
0.49
15
Authors
9