Title | ||
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Challenges in the reproducibility of clinical studies with resting state fMRI: An example in early Parkinson's disease. |
Abstract | ||
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Resting state fMRI (rfMRI) is gaining in popularity, being easy to acquire and with promising clinical applications. However, rfMRI studies, especially those involving clinical groups, still lack reproducibility, largely due to the different analysis settings. This is particularly important for the development of imaging biomarkers. The aim of this work was to evaluate the reproducibility of our recent study regarding the functional connectivity of the basal ganglia network in early Parkinson's disease (PD) (Szewczyk-Krolikowski et al., 2014). In particular, we systematically analysed the influence of two rfMRI analysis steps on the results: the individual cleaning (artefact removal) of fMRI data and the choice of the set of independent components (template) used for dual regression. |
Year | DOI | Venue |
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2016 | 10.1016/j.neuroimage.2015.09.021 | NeuroImage |
Keywords | Field | DocType |
Resting state functional magnetic resonance imaging (rfMRI),Functional connectivity,Artefact removal,Dual regression,Basal ganglia network,Parkinson's disease | Brain mapping,Developmental psychology,Reproducibility,Cognitive neuroscience,Neuroscience,Regression,Regression analysis,Resting state fMRI,Neurology,Psychology,Biomarker (medicine) | Journal |
Volume | Issue | ISSN |
124 | Pt A | 1053-8119 |
Citations | PageRank | References |
5 | 0.49 | 15 |
Authors | ||
9 |
Name | Order | Citations | PageRank |
---|---|---|---|
Ludovica Griffanti | 1 | 653 | 23.24 |
Michal Rolinski | 2 | 5 | 0.83 |
Konrad Szewczyk-Krolikowski | 3 | 5 | 0.49 |
Ricarda A Menke | 4 | 77 | 5.50 |
nicola filippini | 5 | 222 | 11.61 |
Giovanna Zamboni | 6 | 25 | 3.69 |
Mark Jenkinson | 7 | 1879 | 143.90 |
Michele T. M. Hu | 8 | 14 | 2.06 |
Clare Mackay | 9 | 709 | 41.39 |