Paper Info
Title
Evaluation of diffusion kurtosis imaging in ex vivo hypomyelinated mouse brains.
Abstract
Diffusion tensor imaging (DTI), diffusion kurtosis imaging (DKI), and DKI-derived white matter tract integrity metrics (WMTI) were experimentally evaluated ex vivo through comparisons to histological measurements and established magnetic resonance imaging (MRI) measures of myelin in two knockout mouse models with varying degrees of hypomyelination. DKI metrics of mean and radial kurtosis were found to be better indicators of myelin content than conventional DTI metrics. The biophysical WMTI model based on the DKI framework reported on axon water fraction with good accuracy in cases with near normal axon density, but did not provide additional specificity to myelination. Overall, DKI provided additional information regarding white matter microstructure compared with DTI, making it an attractive method for future assessments of white matter development and pathology.
Year
DOI
Venue
2016
10.1016/j.neuroimage.2015.09.028
NeuroImage
Keywords
Field
DocType
AC,AD,AK,CKO,da,Da,De,||,De,⊥,DKI,DTI,DWI,EC,EM,EPG,FA,fa,Fa,fm,FOV,g,GCC,IC,MD,MET2,MidCC,MK,MR,MRI,MWF,PSR,qMT,ρa,RD,RK,ROI,SCC,SEM,SNR,TSC,WM,WMTI,zm
Ex vivo,Biomedical engineering,Diffusion MRI,Neuroscience,Diffusion Kurtosis Imaging,White matter,Cognitive psychology,Psychology,Axon,Kurtosis,Myelin,Magnetic resonance imaging
Journal
Volume
Issue
ISSN
124
Pt A
1053-8119
Citations 
PageRank 
References 
7
0.50
11
Authors
6
Name
Order
Citations
PageRank
Nathaniel D. Kelm1512.70
Kathryn L. West2251.60
Robert P. Carson3512.70
Daniel F. Gochberg4362.87
Kevin C. Ess5160.99
Mark D. Does6986.30