Abstract | ||
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A key measure of white matter health is the g-ratio, which is defined as the ratio between the inner axon radius and the outer, myelinated, axon radius. Recent methods have been proposed to measure the g-ratio noninvasively using the relationship between two magnetic resonance imaging (MRI) measures. While this relationship is intuitive, it predicates on the simplifying assumption that g-ratio is constant across axons. Here, we extend the model to account for a distribution of g-ratio values within an imaging voxel, and evaluate this model with quantitative histology from normal and hypomyelinated mouse brains. (C) 2015 Elsevier Inc. All rights reserved. |
Year | DOI | Venue |
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2016 | 10.1016/j.neuroimage.2015.08.017 | NEUROIMAGE |
Keywords | DocType | Volume |
g-ratio,Myelin,Magnetic resonance imaging,Histology | Journal | 125 |
ISSN | Citations | PageRank |
1053-8119 | 9 | 0.61 |
References | Authors | |
1 | 4 |
Name | Order | Citations | PageRank |
---|---|---|---|
Kathryn L. West | 1 | 25 | 1.60 |
Nathaniel D. Kelm | 2 | 51 | 2.70 |
Robert P. Carson | 3 | 51 | 2.70 |
Mark D. Does | 4 | 98 | 6.30 |