Title
A revised model for estimating g-ratio from MRI.
Abstract
A key measure of white matter health is the g-ratio, which is defined as the ratio between the inner axon radius and the outer, myelinated, axon radius. Recent methods have been proposed to measure the g-ratio noninvasively using the relationship between two magnetic resonance imaging (MRI) measures. While this relationship is intuitive, it predicates on the simplifying assumption that g-ratio is constant across axons. Here, we extend the model to account for a distribution of g-ratio values within an imaging voxel, and evaluate this model with quantitative histology from normal and hypomyelinated mouse brains. (C) 2015 Elsevier Inc. All rights reserved.
Year
DOI
Venue
2016
10.1016/j.neuroimage.2015.08.017
NEUROIMAGE
Keywords
DocType
Volume
g-ratio,Myelin,Magnetic resonance imaging,Histology
Journal
125
ISSN
Citations 
PageRank 
1053-8119
9
0.61
References 
Authors
1
4
Name
Order
Citations
PageRank
Kathryn L. West1251.60
Nathaniel D. Kelm2512.70
Robert P. Carson3512.70
Mark D. Does4986.30