Name
Title | ||
|---|---|---|
Bistability breaks-off deterministic responses to intracortical stimulation during non-REM sleep. |
Abstract | ||
|---|---|---|
During non-rapid eye movement (NREM) sleep (stage N3), when consciousness fades, cortico-cortical interactions are impaired while neurons are still active and reactive. Why is this? We compared cortico-cortical evoked-potentials recorded during wakefulness and NREM by means of time–frequency analysis and phase-locking measures in 8 epileptic patients undergoing intra-cerebral stimulations/recordings for clinical evaluation. We observed that, while during wakefulness electrical stimulation triggers a chain of deterministic phase-locked activations in its cortical targets, during NREM the same input induces a slow wave associated with an OFF-period (suppression of power>20Hz), possibly reflecting a neuronal down-state. Crucially, after the OFF-period, cortical activity resumes to wakefulness-like levels, but the deterministic effects of the initial input are lost, as indicated by a sharp drop of phase-locked activity. These findings suggest that the intrinsic tendency of cortical neurons to fall into a down-state after a transient activation (i.e. bistability) prevents the emergence of stable patterns of causal interactions among cortical areas during NREM. Besides sleep, the same basic neurophysiological dynamics may play a role in pathological conditions in which thalamo-cortical information integration and consciousness are impaired in spite of preserved neuronal activity. |
Year | DOI | Venue |
|---|---|---|
2015 | 10.1016/j.neuroimage.2015.02.056 | NeuroImage |
Keywords | Field | DocType |
CCEP,NREM,PLF,SEEG,SPES,TMS | Developmental psychology,Neuroscience,Premovement neuronal activity,Visual cortex,Non-rapid eye movement sleep,Psychology,Brain activity and meditation,Wakefulness,Eye movement,Slow-wave sleep,Stimulation | Journal |
Volume | ISSN | Citations |
112 | 1053-8119 | 6 |
PageRank | References | Authors |
0.58 | 3 | 13 |
Name | Order | Citations | PageRank |
|---|---|---|---|
| Andrea Pigorini | 1 | 12 | 2.88 |
| Simone Sarasso | 2 | 6 | 0.92 |
| Paola Proserpio | 3 | 6 | 0.58 |
| Caroline Szymanski | 4 | 9 | 1.05 |
| Gabriele Arnulfo | 5 | 16 | 1.28 |
| Silvia Casarotto | 6 | 28 | 2.74 |
| Matteo Fecchio | 7 | 9 | 1.05 |
| Mario Rosanova | 8 | 46 | 5.10 |
| Maurizio Mariotti | 9 | 20 | 2.07 |
| Giorgio Lo Russo | 10 | 6 | 0.58 |
| J Matias Palva | 11 | 20 | 2.07 |
| Lino Nobili | 12 | 16 | 1.28 |
| Marcello Massimini | 13 | 60 | 14.56 |