Name
Abstract | ||
|---|---|---|
While next-generation sequencing technologies have made sequencing genomes faster and more affordable, deciphering the complete genome sequence of an organism remains a significant bioinformatics challenge, especially for large genomes. Low sequence coverage, repetitive elements and short read length make de novo genome assembly difficult, often resulting in sequence and/or fragment “gaps” – uncharacterized nucleotide (N) stretches of unknown or estimated lengths. Some of these gaps can be closed by re-processing latent information in the raw reads. Even though there are several tools for closing gaps, they do not easily scale up to processing billion base pair genomes. |
Year | DOI | Venue |
|---|---|---|
2015 | 10.1186/s12859-015-0663-4 | BMC Bioinformatics |
Keywords | Field | DocType |
Gap closing, Genome finishing, Sealer, Next-generation sequencing, Bloom filters | Genome,Hybrid genome assembly,Biology,Whole genome sequencing,DNA sequencing,Bioinformatics,Genetics,Base pair,DNA microarray,Sequence assembly,Scalability | Journal |
Volume | Issue | ISSN |
16 | 1 | 1471-2105 |
Citations | PageRank | References |
3 | 0.43 | 7 |
Authors | ||
6 | ||
Name | Order | Citations | PageRank |
|---|---|---|---|
| Daniel Paulino | 1 | 3 | 0.77 |
| Rene Warren | 2 | 6 | 1.19 |
| Benjamin Vandervalk | 3 | 121 | 9.60 |
| Anthony Raymond | 4 | 18 | 1.94 |
| Shaun D Jackman | 5 | 72 | 7.37 |
| Inanç Birol | 6 | 5 | 0.82 |