Paper Info
Title
Clustered Desynchronization from High-Frequency Deep Brain Stimulation.
Abstract
While high-frequency deep brain stimulation is a well established treatment for Parkinson's disease, its underlying mechanisms remain elusive. Here, we show that two competing hypotheses, desynchronization and entrainment in a population of model neurons, may not be mutually exclusive. We find that in a noisy group of phase oscillators, high frequency perturbations can separate the population into multiple clusters, each with a nearly identical proportion of the overall population. This phenomenon can be understood by studying maps of the underlying deterministic system and is guaranteed to be observed for small noise strengths. When we apply this framework to populations of Type I and Type II neurons, we observe clustered desynchronization at many pulsing frequencies.
Year
DOI
Venue
2015
10.1371/journal.pcbi.1004673
PLOS COMPUTATIONAL BIOLOGY
Field
DocType
Volume
Population,Deep brain stimulation,Neuroscience,Cortical Synchronization,Biology,Entrainment (chronobiology),Artificial intelligence,Deterministic system,Genetics,Mutually exclusive events
Journal
11
Issue
ISSN
Citations 
12
1553-7358
5
PageRank 
References 
Authors
0.48
7
2
Name
Order
Citations
PageRank
Dan Wilson1173.15
Jeff Moehlis227634.17