Paper Info
Title
Is HNF4A a candidate to study zinc finger protein slug?
Abstract
AbstractProtein-Protein Interactions PPI play a crucial role in deciphering function besides identifying candidates. While the experimental analysis is often time consuming involving number of experiments like pulldown assays, they are not necessarily limiting the ability to detect novel protein interactors. In this work, we discuss the role and putative interactors of SNAI2, a slug protein which is involved in the development of cancer progression. The protein interactions have been deciphered by domain pair exclusion method which gives confidence to already precluded interaction pairs. Additionally, conservation patterns of the slug protein have also been analysed by estimating site-specific evolutionary rates at structural level. Based upon the computational analysis, we consider HNF4A could be a putative candidate to study zinc finger protein slug. We believe, this candidate study augmented with structural conservation will definitely provide novel insights into the design and discovery of new interactions for zinc finger class of proteins besides providing possible clues for discovery of various cancer types associated with this class of proteins.
Year
DOI
Venue
2015
10.1504/IJBRA.2015.070141
Periodicals
Field
DocType
Volume
Slug,Conserved sequence,Protein–protein interaction,Biology,Hepatocyte nuclear factor 4,SNAI2,Bioinformatics,Genetics,Zinc finger,Transcription factor,Peptide sequence
Journal
11
Issue
ISSN
Citations 
4
1744-5485
0
PageRank 
References 
Authors
0.34
4
2
Name
Order
Citations
PageRank
prashanth suravajhala1364.41
Tiratha Raj Singh233.42