Title
Consistency and Stability of Tau-Leaping Schemes for Chemical Reaction Systems
Abstract
We develop a theory of local errors for the explicit and implicit tau-leaping methods for simulating stochastic chemical systems, and we prove that these methods are first-order consistent. Our theory provides local error formulae that could serve as the basis for future stepsize control techniques. We prove that, for the special case of systems with linear propensity functions, both tau-leaping methods are first-order convergent in all moments. We provide a stiff stability analysis of the mean of both leaping methods, and we confirm that the implicit method is unconditionally stable in the mean for stable systems. Finally, we give some theoretical and numerical examples to illustrate these results.
Year
DOI
Venue
2005
10.1137/040603206
MULTISCALE MODELING & SIMULATION
Keywords
Field
DocType
stochastic chemical kinetics,tau-leaping
Mathematical optimization,Tau-leaping,Mathematics,Calculus,Special case
Journal
Volume
Issue
ISSN
4
3
1540-3459
Citations 
PageRank 
References 
28
5.09
0
Authors
4
Name
Order
Citations
PageRank
Muruhan Rathinam18416.48
L Petzold2528109.00
Yang Cao3519.23
Daniel T. Gillespie4355.67