Paper Info
Title
The Disease Portals, disease-gene annotation and the RGD disease ontology at the Rat Genome Database.
Abstract
The Rat Genome Database (RGD; http://rgd.mcw.edu/) provides critical datasets and software tools to a diverse community of rat and non-rat researchers worldwide. To meet the needs of the many users whose research is disease oriented, RGD has created a series of Disease Portals and has prioritized its curation efforts on the datasets important to understanding the mechanisms of various diseases. Gene-disease relationships for three species, rat, human and mouse, are annotated to capture biomarkers, genetic associations, molecular mechanisms and therapeutic targets. To generate gene-disease annotations more effectively and in greater detail, RGD initially adopted the MEDIC disease vocabulary from the Comparative Toxicogenomics Database and adapted it for use by expanding this framework with the addition of over 1000 terms to create the RGD Disease Ontology (RDO). The RDO provides the foundation for, at present, 10 comprehensive disease area-related dataset and analysis platforms at RGD, the Disease Portals. Two major disease areas are the focus of data acquisition and curation efforts each year, leading to the release of the related Disease Portals. Collaborative efforts to realize a more robust disease ontology are underway.
Year
DOI
Venue
2016
10.1093/database/baw034
DATABASE-THE JOURNAL OF BIOLOGICAL DATABASES AND CURATION
Field
DocType
Volume
Genome,Rat Genome Database,Data mining,Disease,World Wide Web,Disease Ontology,Gene ontology,Computer science,Bioinformatics,Molecular Sequence Annotation,Disease Vocabulary,Gene Annotation
Journal
2016
ISSN
Citations 
PageRank 
1758-0463
2
0.40
References 
Authors
9
10
Name
Order
Citations
PageRank
G. Thomas Hayman113213.77
Stanley J. F. Laulederkind215015.81
Jennifer R. Smith313218.16
Shur-Jen Wang413813.80
Victoria Petri513317.76
Rajni Nigam616926.98
Marek Tutaj7557.43
Jeff de Pons8839.84
Melinda R Dwinell912517.82
Mary Shimoyama1020035.46