Paper Info
Title
FARE-CAFE: a database of functional and regulatory elements of cancer-associated fusion events
Abstract
Chromosomal translocation (CT) is of enormous clinical interest because this disorder is associated with various major solid tumors and leukemia. A tumor-specific fusion gene event may occur when a translocation joins two separate genes. Currently, various CT databases provide information about fusion genes and their genomic elements. However, no database of the roles of fusion genes, in terms of essential functional and regulatory elements in oncogenesis, is available. FARE-CAFE is a unique combination of CTs, fusion proteins, protein domains, domain-domain interactions, protein-protein interactions, transcription factors and microRNAs, with subsequent experimental information, which cannot be found in any other CT database. Genomic DNA information including, for example, manually collected exact locations of the first and second break points, sequences and karyotypes of fusion genes are included. FARE-CAFE will substantially facilitate the cancer biologist's mission of elucidating the pathogenesis of various types of cancer. This database will ultimately help to develop 'novel' therapeutic approaches.
Year
DOI
Venue
2015
10.1093/database/bav086
DATABASE-THE JOURNAL OF BIOLOGICAL DATABASES AND CURATION
Field
DocType
Volume
Carcinogenesis,Fusion gene,Gene,Protein domain,Fusion protein,Biology,Bioinformatics,Genetics,Database,Transcription factor,Cancer,genomic DNA
Journal
2015
ISSN
Citations 
PageRank 
1758-0463
0
0.34
References 
Authors
16
9
Name
Order
Citations
PageRank
Praveen Kumar Korla100.34
Jack Cheng200.34
chienhung huang35811.65
jeffrey j p tsai4989156.23
Yu-Hsuan Liu502.03
Nilubon Kurubanjerdjit652.91
Wen-Tsong Hsieh740.86
Huey-Yi Chen800.34
kalok ng92910.11