Paper Info
Title
Networks As A Privileged Way To Develop Mesoscopic Level Approaches In Systems Biology
Abstract
The methodologies advocated in computational biology are in many cases proper system-level approaches. These methodologies are variously connected to the notion of "mesosystem" and thus on the focus on relational structures that are at the basis of biological regulation. Here, I describe how the formalization of biological systems by means of graph theory constitutes an extremely fruitful approach to biology. I suggest the epistemological relevance of the notion of graph resides in its multilevel character allowing for a natural "middle-out" causation making largely obsolete the traditional opposition between "top-down" and "bottom-up" styles of reasoning, so fulfilling the foundation dream of systems science of a direct link between systems analysis and the underlying physical reality.
Year
DOI
Venue
2014
10.3390/systems2020237
SYSTEMS
Keywords
Field
DocType
bioinformatics, graph theory, chemistry, molecular biology, systems analysis
Graph theory,Systems science,Cognitive science,Computer science,Causation,Systems analysis,Systems biology,Artificial intelligence,Natural language processing,Opposition (planets),Biological regulation,Complex systems biology
Journal
Volume
Issue
ISSN
2
2
2079-8954
Citations 
PageRank 
References 
1
0.38
5
Authors
1
Name
Order
Citations
PageRank
Alessandro Giuliani117025.21