Title
Constrained Maximum Likelihood Estimation of Relative Abundances of Protein Conformation in a Heterogeneous Mixture From Small Angle X-Ray Scattering Intensity Measurements.
Abstract
In this paper, we describe a model for maximum likelihood estimation (MLE) of the relative abundances of different conformations of a protein in a heterogeneous mixture from small angle X-ray scattering (SAXS) intensities. To consider cases where the solution includes intermediate or unknown conformations, we develop a subset selection method based on k-means clustering and the Cramér-Rao bound on...
Year
DOI
Venue
2015
10.1109/TSP.2015.2455515
IEEE Transactions on Signal Processing
Keywords
Field
DocType
Proteins,Maximum likelihood estimation,Noise,Noise measurement,X-ray scattering,Scattering
Mathematical optimization,Monte Carlo method,Small-angle X-ray scattering,Scattering,Molecular dynamics,Cluster analysis,Convex optimization,Basis set,Mathematics,Protein structure
Journal
Volume
Issue
ISSN
63
20
1053-587X
Citations 
PageRank 
References 
2
0.91
0
Authors
6
Name
Order
Citations
PageRank
A. Emre Onuk121.25
Murat Akçakaya25921.15
Jaydeep P. Bardhan3568.55
Deniz Erdogmus41299169.92
Dana H Brooks521561.52
Lee Makowski622.60