Paper Info
Title
A Comparison of Theory-Based and Experimentally Determined Myocardial Signal Intensity Correction Methods in First-Pass Perfusion Magnetic Resonance Imaging.
Abstract
Objectives. To evaluate the impact of correcting myocardial signal saturation on the accuracy of absolute myocardial blood flow (MBF) measurements. Materials and Methods. We performed 15 dual bolus first-pass perfusion studies in 7 dogs during global coronary vasodilation and variable degrees of coronary artery stenosis. We compared microsphere MBF to MBF calculated from uncorrected and corrected MRI signal. Four correction methods were tested, two theoretical methods (Th1 and Th2) and two empirical methods (Em1 and Em2). Results. The correlations with microsphere MBF (n = 90 segments) were: uncorrected (y = 0.47x + 1.1, r = 0.70), Th1 (y = 0.53x + 1.0, r = 0.71), Th2 (y = 0.62x + 0.86, r = 0.73), Em1 (y = 0.82x + 0.86, r = 0.77), and Em2 (y = 0.72x + 0.84, r = 0.75). All corrected methods were not significantly different from microspheres, while uncorrected MBF values were significantly lower. For the top 50% of microsphere MBF values, flows were significantly underestimated by uncorrected SI (31%), Th1(25%), andTh2 (19%), while Em1 (1%), and Em2(9%) were similar to microsphere MBF. Conclusions. Myocardial signal saturation should be corrected prior to flow modeling to avoid underestimation of MBF by MR perfusion imaging.
Year
DOI
Venue
2015
10.1155/2015/843741
COMPUTATIONAL AND MATHEMATICAL METHODS IN MEDICINE
Field
DocType
Volume
Perfusion scanning,Nuclear medicine,Artery,Blood flow,Magnetic resonance angiography,Microsphere,Bolus (digestion),Medicine,Coronary circulation,Perfusion
Journal
2015
ISSN
Citations 
PageRank 
1748-670X
0
0.34
References 
Authors
0
5
Name
Order
Citations
PageRank
Jacob U. Fluckiger100.68
Brandon C Benefield200.34
Lara Bakhos300.34
Kathleen R Harris400.34
Daniel C. Lee531938.68