Title
Predicting Pure Amnestic Mild Cognitive Impairment Conversion to Alzheimer's Disease Using Joint Modeling of Imaging and Clinical Data
Abstract
Predicting the conversion of amnestic mild cognitive impairment (aMCI) to Alzheimer's disease (AD) is a challenging problem for which machine learning could be of great use. In this work, we aim at assessing the independent and joint value of imaging (structural MRI, resting-state functional MRI (rsfMRI)) and clinical data in classifying stable versus progressive aMCI. Surprisingly, we found no previous studies using rsfMRI to predict conversion of MCI to AD. We use singular value decomposition as a feature extractor before combining modalities. We reach accuracies of up to 82% using rsfMRI, 86% using sMRI and rsfMRI combined, and 77% using a combination of all modalities.
Year
DOI
Venue
2015
10.1109/PRNI.2015.23
PRNI
Keywords
Field
DocType
Alzheimer's disease, amnestic mild cognitive impairment, magnetic resonance imaging, machine learning, singular value decomposition
Modalities,Disease,Psychology,Speech recognition,Extractor,Cognitive impairment,Magnetic resonance imaging
Conference
Citations 
PageRank 
References 
1
0.35
7
Authors
8
Name
Order
Citations
PageRank
V. Kebets131.05
Jonas Richiardi254729.41
M. van Assche310.35
R. Goldstein410.35
M. van der Meulen510.35
P Vuilleumier643540.82
Dimitri Van De Ville71656118.48
Frédéric Assal871.23