Name
Abstract | ||
|---|---|---|
There is a growing interest in identifying neuroimaging-based biomarkers for Parkinson's disease (PD), a progressive neurodegenerative disorder in which the major pathologic substrate is the loss of pigmented dopaminergic neurons in the substantia nigra (SN). Recently, an MRI technique dubbed “neuromelanin-sensitive MRI” (NM-MRI), has been found to provide notable contrast between the SN and surrounding brain tissues with potential applications as biomarker of PD. The contrast in NM-MRI has been associated with magnetization transfer (MT) effects, and thus the goal of this study was to characterize the impact of MT on NM-MRI, and to demonstrate the feasibility of performing quantitative MT (qMT) imaging in human SN. The results of this study demonstrate that high-resolution rapid qMT imaging of the SN can be reliably obtained within reasonable scan times, thereby can be translatable into clinical practice. |
Year | DOI | Venue |
|---|---|---|
2015 | 10.1109/EMBC.2015.7319619 | EMBC |
Field | DocType | Volume |
Neuroscience,Computer science,Substantia nigra,Quantitative imaging,Nuclear magnetic resonance | Conference | 2015 |
ISSN | Citations | PageRank |
1557-170X | 1 | 0.37 |
References | Authors | |
3 | 7 | |
Name | Order | Citations | PageRank |
|---|---|---|---|
| Paula Trujillo | 1 | 1 | 0.37 |
| Alex K. Smith | 2 | 4 | 1.16 |
| Paul E. Summers | 3 | 1 | 0.37 |
| Luca M. Mainardi | 4 | 1 | 0.70 |
| Sergio Cerutti | 5 | 129 | 21.96 |
| Seth A. Smith | 6 | 17 | 2.02 |
| Antonella Costa | 7 | 1 | 0.37 |