Title
A New Biclustering Algorithm for Time-Series Gene Expression Data Analysis
Abstract
Biclustering algorithm is used to find local patterns as an important tool in the analysis of gene expression data. However, most of the biclusters found by existing biclustering algorithms consist of non-continuous columns. It is not suitable for time series gene expression data, which has not been extensively studied. This paper presents an efficient exact algorithm to search contiguous column coherent evolution biclusters in time-series data. The first step of the algorithm is to transform the original matrix into the difference matrix, then starting from the column pattern consisting of continuous k columns, gradually obtain longer patterns composed of more columns by using the prefix tree and nodes-update-strategy to improve the efficiency of the algorithm. Experimental results on real data show that the algorithm can find biclusters with statistically significance and strong biological relevance.
Year
DOI
Venue
2014
10.1109/CIS.2014.164
CIS
Keywords
Field
DocType
NETWORKS
Time series,Algorithm design,Exact algorithm,Computer science,Matrix (mathematics),Matrix difference equation,Support vector machine,Algorithm,Artificial intelligence,Biclustering,Trie,Machine learning
Conference
Citations 
PageRank 
References 
0
0.34
11
Authors
7
Name
Order
Citations
PageRank
Yun Xue165.30
Zhengling Liao253.44
Meihang Li383.83
Jie Luo470673.44
Xiao-Hui Hu5105.55
Guiyin Luo600.34
Wen-Sheng Chen7101.38