Paper Info
Title
Ground Truth for Diffusion MRI in Cancer: A Model-Based Investigation of a Novel Tissue-Mimetic Material
Abstract
This work presents preliminary results on the development, characterisation, and use of a novel physical phantom designed as a simple mimic of tumour cellular structure, for diffusion-weighted magnetic resonance imaging (DW-MRI) applications. The phantom consists of a collection of roughly spherical, micron-sized core–shell polymer ‘cells’, providing a system whose ground truth microstructural properties can be determined and compared with those obtained from modelling the DW-MRI signal. A two-compartment analytic model combining restricted diffusion inside a sphere with hindered extracellular diffusion was initially investigated through Monte Carlo diffusion simulations, allowing a comparison between analytic and simulated signals. The model was then fitted to DW-MRI data acquired from the phantom over a range of gradient strengths and diffusion times, yielding estimates of ‘cell’ size, intracellular volume fraction and the free diffusion coefficient. An initial assessment of the accuracy and precision of these estimates is provided, using independent scanning electron microscope measurements and bootstrap-style simulations. Such phantoms may be useful for testing microstructural models relevant to the characterisation of tumour tissue.
Year
DOI
Venue
2015
10.1007/978-3-319-19992-4_14
IPMI
Field
DocType
Volume
Volume fraction,Diffusion MRI,Monte Carlo method,Pattern recognition,Biological system,Computer science,Restricted Diffusion,Scanning electron microscope,Imaging phantom,Ground truth,Artificial intelligence,Accuracy and precision
Conference
24
ISSN
Citations 
PageRank 
1011-2499
2
0.44
References 
Authors
2
5
Name
Order
Citations
PageRank
Damien J. McHugh120.44
Feng-Lei Zhou231.55
Penny L. Hubbard Cristinacce320.44
Josephine H. Naish442.06
Geoffrey J. M. Parker544439.62