Paper Info
Title
Interventional Photoacoustic Imaging of the Human Placenta with Ultrasonic Tracking for Minimally Invasive Fetal Surgeries.
Abstract
Image guidance plays a central role in minimally invasive fetal surgery such as photocoagulation of inter-twin placental anastomosing vessels to treat twin-to-twin transfusion syndrome TTTS. Fetoscopic guidance provides insufficient sensitivity for imaging the vasculature that lies beneath the fetal placental surface due to strong light scattering in biological tissues. Incomplete photocoagulation of anastamoses is associated with postoperative complications and higher perinatal mortality. In this study, we investigated the use of multi-spectral photoacoustic PA imaging for better visualization of the placental vasculature. Excitation light was delivered with an optical fiber with dimensions that are compatible with the working channel of a fetoscope. Imaging was performed on an ex vivo normal term human placenta collected at Caesarean section birth. The photoacoustically-generated ultrasound signals were received by an external clinical linear array ultrasound imaging probe. A vein under illumination on the fetal placenta surface was visualized with PA imaging, and good correspondence was obtained between the measured PA spectrum and the optical absorption spectrum of deoxygenated blood. The delivery fiber had an attached fiber optic ultrasound sensor positioned directly adjacent to it, so that its spatial position could be tracked by receiving transmissions from the ultrasound imaging probe. This study provides strong indications that PA imaging in combination with ultrasonic tracking could be useful for detecting the human placental vasculature during minimally invasive fetal surgery.
Year
DOI
Venue
2015
10.1007/978-3-319-24553-9_46
MICCAI
Field
DocType
Volume
Biomedical engineering,Computer vision,Ultrasonic sensor,Photoacoustic imaging in biomedicine,Fetus,Computer science,Vein,Ultrasound imaging,Artificial intelligence,Fetal surgery,Placenta,Ultrasound
Conference
9349
ISSN
Citations 
PageRank 
0302-9743
2
0.69
References 
Authors
1
11
Name
Order
Citations
PageRank
Wenfeng Xia163.07
Efthymios Maneas293.75
Daniil I. Nikitichev321.36
Charles A. Mosse431.35
Gustavo Sato Dos Santos5274.10
Tom Vercauteren61956108.68
Anna L. David7525.70
Jan Deprest812320.45
Sébastien Ourselin92499237.61
Paul C. Beard10142.69
Adrien E. Desjardins11165.99