Title
Combining Unsupervised Feature Learning and Riesz Wavelets for Histopathology Image Representation: Application to Identifying Anaplastic Medulloblastoma.
Abstract
Medulloblastoma MB is a type of brain cancer that represent roughly 25% of all brain tumors in children. In the anaplastic medulloblastoma subtype, it is important to identify the degree of irregularity and lack of organizations of cells as this correlates to disease aggressiveness and is of clinical value when evaluating patient prognosis. This paper presents an image representation to distinguish these subtypes in histopathology slides. The approach combines learned features from i an unsupervised feature learning method using topographic independent component analysis that captures scale, color and translation invariances, and ii learned linear combinations of Riesz wavelets calculated at several orders and scales capturing the granularity of multiscale rotation-covariant information. The contribution of this work is to show that the combination of two complementary approaches for feature learning unsupervised and supervised improves the classification performance. Our approach outperforms the best methods in literature with statistical significance, achieving 99% accuracy over region-based data comprising 7,500 square regions from 10 patient studies diagnosed with medulloblastoma 5 anaplastic and 5 non-anaplastic.
Year
DOI
Venue
2015
10.1007/978-3-319-24553-9_71
MICCAI
Field
DocType
Volume
Linear combination,Pattern recognition,Convolutional neural network,Computer science,Local binary patterns,Medulloblastoma,Image representation,Anaplastic Medulloblastoma,Artificial intelligence,Machine learning,Feature learning,Wavelet
Conference
9349
ISSN
Citations 
PageRank 
0302-9743
4
0.45
References 
Authors
5
9
Name
Order
Citations
PageRank
Sebastian Otálora1103.07
Angel Cruz-Roa221112.37
John E. Arevalo31458.72
Manfredo Atzori4479.54
Anant Madabhushi51736139.21
Alexander R Judkins6151.87
Fabio A. González756655.03
Henning Müller82538218.89
Adrien Depeursinge941838.83