Name
Title | ||
|---|---|---|
Who Is Talking to Whom: Synaptic Partner Detection in Anisotropic Volumes of Insect Brain |
Abstract | ||
|---|---|---|
Automated reconstruction of neural connectivity graphs from electron microscopy image stacks is an essential step towards large-scale neural circuit mapping. While significant progress has recently been made in automated segmentation of neurons and detection of synapses, the problem of synaptic partner assignment for polyadic one-to-many synapses, prevalent in the Drosophila brain, remains unsolved. In this contribution, we propose a method which automatically assigns pre- and postsynaptic roles to neurites adjacent to a synaptic site. The method constructs a probabilistic graphical model over potential synaptic partner pairs which includes factors to account for a high rate of one-to-many connections, as well as the possibility of the same neuron to be pre-synaptic in one synapse and post-synaptic in another. The algorithm has been validated on a publicly available stack of ssTEM images of Drosophila neural tissue and has been shown to reconstruct most of the synaptic relations correctly. |
Year | DOI | Venue |
|---|---|---|
2015 | 10.1007/978-3-319-24553-9_81 | MICCAI |
Keywords | Field | DocType |
Circuit reconstruction,graphical model,electron microscopy | Graph,Synapse,Pattern recognition,Segmentation,Computer science,Postsynaptic potential,Artificial intelligence,Probabilistic logic,Graphical model,Neuron | Conference |
Volume | ISSN | Citations |
9349 | 0302-9743 | 2 |
PageRank | References | Authors |
0.41 | 8 | 4 |
Name | Order | Citations | PageRank |
|---|---|---|---|
| Anna Kreshuk | 1 | 8 | 5.02 |
| Jan Funke | 2 | 50 | 7.48 |
| Albert Cardona | 3 | 101 | 10.20 |
| Fred A. Hamprecht | 4 | 962 | 76.24 |