Title
A SystemC Platform for Signal Transduction Modelling and Simulation in Systems Biology
Abstract
Signal transduction is a class of cell's biological processes, which are commonly represented as highly concurrent reactive systems. In the Systems Biology community, modelling and simulation of signal transduction require overcoming issues like discrete event-based execution of complex systems, description from building blocks through composition and encapsulation, description at different levels of granularity, methods for abstraction and refinement. This paper presents a signal transduction modelling and simulation platform based on SystemC, and shows how the platform allows handling the system complexity by modelling it at different abstraction levels. The paper reports the results obtained by applying the platform to model the intracellular signalling network controlling integrin activation mediating leukocyte recruitment from the blood into the tissues.
Year
DOI
Venue
2015
10.1145/2742060.2742115
ACM Great Lakes Symposium on VLSI
Field
DocType
Citations 
Complex system,Signalling,Modeling and simulation,Computer science,Systems biology,Theoretical computer science,Real-time computing,SystemC,Signal transduction,Granularity,Reactive system,Distributed computing
Conference
1
PageRank 
References 
Authors
0.36
6
5
Name
Order
Citations
PageRank
Rosario Distefano1112.13
Franco Fummi221.05
Carlo Laudanna310.36
Nicola Bombieri431.07
Rosalba Giugno581749.45