Paper Info
Title
Semantic Web Ontology and Data Integration: a Case Study in Aiding Psychiatric Drug Repurposing.
Abstract
There remain significant difficulties selecting probable candidate drugs from existing databases. We describe an ontology-oriented approach to represent the nexus between genes, drugs, phenotypes, symptoms, and diseases from multiple information sources. We also report a case study in which we attempted to explore candidate drugs effective for bipolar disorder and epilepsy. We constructed an ontology incorporating knowledge between the two diseases and performed semantic reasoning tasks with the ontology. The results suggested 48 candidate drugs that hold promise for further breakthrough. The evaluation demonstrated the validity our approach. Our approach prioritizes the candidate drugs that have potential associations among genes, phenotypes and symptoms, and thus facilitates the data integration and drug repurposing in psychiatric disorders.
Year
DOI
Venue
2016
10.3233/978-1-61499-564-7-1051
Studies in Health Technology and Informatics
Keywords
DocType
Volume
Drug Repurposing,Ontology,Data Integration
Conference
216
ISSN
Citations 
PageRank 
0926-9630
1
0.36
References 
Authors
0
3
Name
Order
Citations
PageRank
Chen Liang112618.00
Jingchun Sun222717.08
Cui Tao33512.77