Title
A Genetic Algorithm for the selection of structural MRI features for classification of Mild Cognitive Impairment and Alzheimer's Disease
Abstract
This work investigates the problem of feature selection in neuroimaging features from structural MRI brain images for the classification of subjects as healthy controls, suffering from Mild Cognitive Impairment or Alzheimer's Disease. A Genetic Algorithm wrapper method for feature selection is adopted in conjunction with a Support Vector Machine classifier. In very large feature sets, feature selection is found to be redundant as the accuracy is often worsened when compared to an Support Vector Machine with no feature selection. However, when just the hippocampal subfields are used, feature selection shows a significant improvement of the classification accuracy. Three-class Support Vector Machines and two-class Support Vector Machines combined with weighted voting are also compared with the former and found more useful. The highest accuracy achieved at classifying the test data was 65.5% using a genetic algorithm for feature selection with a three-class Support Vector Machine classifier.
Year
DOI
Venue
2015
10.1109/BIBM.2015.7359909
IEEE International Conference on Bioinformatics and Biomedicine
Field
DocType
ISSN
Disease,Pattern recognition,Feature selection,Computer science,Support vector machine,Weighted voting,Artificial intelligence,Test data,Neuroimaging,Statistical classification,Genetic algorithm,Machine learning
Conference
2156-1125
Citations 
PageRank 
References 
1
0.35
8
Authors
3
Name
Order
Citations
PageRank
Alexander Luke Spedding110.69
Giuseppe Di Fatta252939.23
Mario Cannataro31095123.23