Paper Info
Title
mCSM-AB: a web server for predicting antibody-antigen affinity changes upon mutation with graph-based signatures.
Abstract
Computational methods have traditionally struggled to predict the effect of mutations in antibody-antigen complexes on binding affinity. This has limited their usefulness during antibody engineering and development, and their ability to predict biologically relevant escape mutations. Here we present mCSM-AB, a user-friendly web server for accurately predicting antibody-antigen affinity changes upon mutation which relies on graph-based signatures. We show that mCSM-AB performs better than comparable methods that have been previously used for antibody engineering. mCSM-AB web server is available at http://structure.bioc.cam.ac.uk/mcsm_ab.
Year
DOI
Venue
2016
10.1093/nar/gkw458
NUCLEIC ACIDS RESEARCH
Field
DocType
Volume
Graph,Antibody antigen,Biology,Antigen,Protein engineering,Bioinformatics,Computational biology,Genetics,Antigen-Antibody Complex,Web server,Mutation
Journal
44
Issue
ISSN
Citations 
W1
0305-1048
2
PageRank 
References 
Authors
0.43
4
2
Name
Order
Citations
PageRank
Douglas E. V. Pires19110.73
David B Ascher26710.18