Name
Title | ||
|---|---|---|
Measuring specific receptor binding of a PET radioligand in human brain without pharmacological blockade: The genomic plot. |
Abstract | ||
|---|---|---|
PET studies allow in vivo imaging of the density of brain receptor species. The PET signal, however, is the sum of the fraction of radioligand that is specifically bound to the target receptor and the non-displaceable fraction (i.e. the non-specifically bound radioligand plus the free ligand in tissue). Therefore, measuring the non-displaceable fraction, which is generally assumed to be constant across the brain, is a necessary step to obtain regional estimates of the specific fractions. |
Year | DOI | Venue |
|---|---|---|
2016 | 10.1016/j.neuroimage.2016.01.058 | NeuroImage |
Keywords | Field | DocType |
Non-displaceable binding,PET,Lassen plot,Allen brain atlas,Pharmacological displacement,Pharmacological blockade,mRNA | Brain mapping,Population,Neuroscience,Brain atlas,Radioligand,Ligand (biochemistry),Psychology,Cognitive psychology,Receptor,Human brain,Computational biology,Preclinical imaging | Journal |
Volume | ISSN | Citations |
130 | 1053-8119 | 6 |
PageRank | References | Authors |
0.64 | 3 | 6 |
Name | Order | Citations | PageRank |
|---|---|---|---|
| Mattia Veronese | 1 | 9 | 4.47 |
| Paolo Zanotti-Fregonara | 2 | 12 | 2.89 |
| Gaia Rizzo | 3 | 18 | 6.13 |
| Alessandra Bertoldo | 4 | 32 | 10.25 |
| Robert B Innis | 5 | 12 | 2.22 |
| Federico E. Turkheimer | 6 | 57 | 11.41 |