Paper Info
Title
Relationship between digital information and thermodynamic stability in bacterial genomes.
Abstract
Ever since the introduction of the Watson-Crick model, numerous efforts have been made to fully characterize the digital information content of the DNA. However, it became increasingly evident that variations of DNA configuration also provide an "analog" type of information related to the physicochemical properties of the DNA, such as thermodynamic stability and supercoiling. Hence, the parallel investigation of the digital information contained in the base sequence with associated analog parameters is very important for understanding the coding capacity of the DNA. In this paper, we represented analog information by its thermodynamic stability and compare it with digital information using Shannon and Gibbs entropy measures on the complete genome sequences of several bacteria, including (), (), (), and (). Furthermore, the link to the broader classes of functional gene groups (anabolic and catabolic) is examined. Obtained results demonstrate the couplings between thermodynamic stability and digital sequence organization in the bacterial genomes. In addition, our data suggest a determinative role of the genome-wide distribution of DNA thermodynamic stability in the spatial organization of functional gene groups.
Year
DOI
Venue
2016
10.1186/s13637-016-0037-x
EURASIP J. Bioinformatics and Systems Biology
Keywords
Field
DocType
Gibbs entropy,Sequence analysis,Shannon entropy,Thermodynamic stability
Genome,Gene,Biology,DNA,DNA supercoil,Streptomyces coelicolor,Bioinformatics,Bacillus subtilis,Bacterial genome size,Sequence analysis
Journal
Volume
Issue
ISSN
2016
1
1687-4153
Citations 
PageRank 
References 
3
0.41
4
Authors
4
Name
Order
Citations
PageRank
Dawit Nigatu1102.18
Werner Henkel214325.07
Patrick Sobetzko330.41
Georgi Muskhelishvili4182.09