Title
Mining Patterns of Disease Progression: A Topic-Model-Based Approach.
Abstract
Knowledge of how diseases progress and transform is crucial for clinical decision making. Frequent pattern mining techniques, such as sequential pattern mining (SPM) algorithms, can automatically extract such knowledge from large collections of electronic medical records (EMR). However, EMR data are usually unorganized and highly noisy. Finding meaningful disease patterns often calls for manual manipulation such as cohort and feature selection on EMR data by medical professionals. In this paper, we propose a topic-model-based SPM approach to find disease progression patterns from diagnostic records. We improve the traditional SPM algorithms by filtering and grouping the diagnosis sequences according to different clinical topics. These topics represent certain clinical conditions with closely related diagnoses, and are detected without prior medical knowledge. The experiment on real-world EMR data shows that our approach is able to find meaningful progression patterns with less noises, and can help quickly identify interesting patterns related to a certain clinical condition with less human effort.
Year
DOI
Venue
2016
10.3233/978-1-61499-678-1-354
Studies in Health Technology and Informatics
Keywords
Field
DocType
Clinical Informatics,Computer Assisted Medical Decision Support,Advanced Analytics and Big Data
Knowledge management,Disease progression,Topic model,Medicine
Conference
Volume
ISSN
Citations 
228
0926-9630
0
PageRank 
References 
Authors
0.34
0
4
Name
Order
Citations
PageRank
Lingxiao Zhang100.68
Junfeng Zhao273.86
Ya-sha Wang330337.40
Bing Xie45211.39