Name
Title | ||
|---|---|---|
A novel mathematical model of ATM/p53/NF- κB pathways points to the importance of the DDR switch-off mechanisms. |
Abstract | ||
|---|---|---|
BackgroundAtaxia telangiectasia mutated (ATM) is a detector of double-strand breaks (DSBs) and a crucial component of the DNA damage response (DDR) along with p53 and NF- κB transcription factors and Wip1 phosphatase. Despite the recent advances in studying the DDR, the mechanisms of cell fate determination after DNA damage induction is still poorly understood. |
Year | DOI | Venue |
|---|---|---|
2016 | 10.1186/s12918-016-0293-0 | BMC Systems Biology |
Keywords | Field | DocType |
Mathematical, Model, Deterministic, Stochastic, DNA damage, ATM, Wip1, p53 | NFKB1,NF-κB,Ataxia Telangiectasia Mutated Proteins,Biology,Cell biology,DNA damage,Signal transduction,Cell fate determination,Bioinformatics,Ataxia-telangiectasia,Transcription factor | Journal |
Volume | Issue | ISSN |
10 | 1 | 1752-0509 |
Citations | PageRank | References |
3 | 0.52 | 1 |
Authors | ||
6 | ||
Name | Order | Citations | PageRank |
|---|---|---|---|
| Katarzyna Jonak | 1 | 10 | 2.67 |
| Monika Kurpas | 2 | 6 | 1.91 |
| Katarzyna Szoltysek | 3 | 6 | 1.57 |
| Patryk Janus | 4 | 6 | 2.59 |
| Agata Abramowicz | 5 | 6 | 1.23 |
| Krzysztof Puszyński | 6 | 12 | 5.91 |