Paper Info
Title
Epigenetic-IC: A fully integrated sensing platform for epigenetic reaction monitoring
Abstract
This paper presents a pH-based System-on-Chip DNA methylation quantification platform for real time monitoring of DNA methylation ratio in target genes. The architecture forms a novel autonomous system, capable of providing diagnostic information on the progression of a disease, notably cancer. The system is equipped with drift and trapped charge compensation schemes based on differential measurements and an auto-calibration algorithm. The simulated system in 0.35μm CMOS technology achieves a power consumption of 0.997mW, with a DNA methylation ratio output sensitivity of 0.1%. The ISFET-based detection platform occupies a total of 901μm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> and allows the calculation of DNA methylation ratio in pH-monitored DNA methylation based reactions.
Year
DOI
Venue
2016
10.1109/ISCAS.2016.7527236
2016 IEEE International Symposium on Circuits and Systems (ISCAS)
Keywords
Field
DocType
Epigenetic-IC,fully integrated sensing platform,epigenetic reaction monitoring,pH-based system-on-chip DNA methylation quantification platform,real-time monitoring,DNA methylation ratio,target genes,autonomous system,diagnostic information,disease progression,cancer,trapped charge compensation schemes,differential measurements,autocalibration algorithm,simulated system,CMOS technology,power consumption,DNA methylation ratio output sensitivity,ISFET-based detection platform,pH-monitored DNA methylation based reactions
System on a chip,Computer science,DNA,DNA methylation,CMOS,Electronic engineering,Methylation,Autonomous system (mathematics),A-DNA,Epigenetics
Conference
ISSN
ISBN
Citations 
0271-4302
978-1-4799-5342-4
0
PageRank 
References 
Authors
0.34
3
4
Name
Order
Citations
PageRank
Alexandros Koutsos100.34
Melpomeni Kalofonou243.62
Mohammadreza Sohbati301.01
Christofer Toumazou426559.06