Name
Abstract | ||
|---|---|---|
In plant mitochondria an essential mechanism for gene expression is RNA editing, often influencing the synthesisof functional proteins. RNA editing alters the linearity of genetic information transfer. Indeed it causesdifferences between RNAs and their coding DNA sequences that hinder both experimental and computationalresearch of genes. Therefore common software tools for gene search, successfully applied to find canonicalgenes, often fail in discovering genes encrypted in the genome of plants.Here we propose a novel strategy useful to identify candidate coding sequences resulting from possible editingsubstitutions. In particular, we consider c!u substitutions leading to the creation of new start and stop codonsin the mitochondrial DNA of a given input organism. We try to mimic the natural RNA editing mechanism,in order to generate candidate Open Reading Frame sequences that could code for novel, uncharacterizedproteins. Results obtained analyzing the mtDNA of Oryza sativa are supportive of this approach, since weidentified thirteen Open Reading Frame sequences transcribed in Oryza, that do not correspond to alreadyknown proteins. Five of the corresponding amino acid sequences present high homologies with proteins alreadydiscovered in other organisms, whereas, for the remaining ones, no such homology was detected. |
Year | Venue | Field |
|---|---|---|
2016 | BIOINFORMATICS | Genome,Gene,Biology,Gene expression,RNA editing,Open reading frame,Mitochondrial DNA,Bioinformatics,Stop codon,Genetics,Sequence analysis |
DocType | Citations | PageRank |
Conference | 0 | 0.34 |
References | Authors | |
0 | 6 | |
Name | Order | Citations | PageRank |
|---|---|---|---|
| Fabio Fassetti | 1 | 223 | 22.68 |
| Claudia Giallombardo | 2 | 0 | 0.34 |
| Ofelia Leone | 3 | 0 | 1.35 |
| Luigi Palopoli | 4 | 1387 | 185.69 |
| Simona E. Rombo | 5 | 192 | 22.21 |
| Adolfo Saiardi | 6 | 0 | 1.01 |