Paper Info
Title
Sloppy/Stiff Parameters Rankings in Sensitivity Analysis of Signaling Pathways.
Abstract
Sensitivity analysis methods have been developed for over half a century. However, their application to systems biology is a relatively new concept and has not been fully investigated. In this paperwe focus on creating parameter rankings based on sloppy/stiff parameter sensitivity analysis, that can be used to find the most important parameters and processes (that have the greatest impact on the system output) and subsequently can be used to reduce the number of experiments needed to precisely estimate parameters values or to indicate molecular targets for new drugs. In order to test the proposed procedure we performed sensitivity analysis of the HSF/NF-кB pathway model - a model combining two signaling pathways essential for cell survival.
Year
DOI
Venue
2016
10.5220/0005820002780283
BIOINFORMATICS
Field
DocType
Citations 
Computer science,Artificial intelligence,Machine learning
Conference
0
PageRank 
References 
Authors
0.34
0
6
Name
Order
Citations
PageRank
Malgorzata Kardynska100.68
Jaroslaw Smieja285.49
Anna Naumowicz300.68
Patryk Janus462.59
Piotr Widlak522.09
Marek Kimmel614520.47