Name
Abstract | ||
|---|---|---|
This paper describes the surface-patterned polydimethylsiloxane (PDMS) pillar arrays for enhancing cell alignment and contraction force in cardiomyocytes. The PDMS micropillar (mu pillar) arrays with microgrooves (mu grooves) were fabricated using a unique micro-mold made using SU-8 double layer processes. The spring constant of the pillar arrays was experimentally confirmed using atomic force microscopy (AFM). After culturing cardiac cells on the two different types of pillar arrays, with and without grooves on the top of pillar, the characteristics of the cardiomyocytes were analyzed using a custom-made image analysis system. The alignment of the cardiomyocytes on the grooves of the pillars was clearly observed using a DAPI staining process. The mechanical force generated by the contraction force of the cardiomyocytes was derived from the displacement of the pillar arrays. The contraction force of the cardiomyocytes aligned on the grooves was 20% higher than that of the pillar arrays without grooves. The experimental results prove that applied geometrical stimulus is an effective method for aligning and improving the contraction force of cardiomyocytes. |
Year | DOI | Venue |
|---|---|---|
2016 | 10.3390/s16081258 | SENSORS |
Keywords | Field | DocType |
polydimethylsiloxane pillar,cardiomyocyte,microgrooves,contraction force,drug screening | Biomedical engineering,Nanotechnology,Analytical chemistry,Polydimethylsiloxane,Atomic force microscopy,Engineering,Pillar,Double layer (surface science) | Journal |
Volume | Issue | Citations |
16 | 8.0 | 0 |
PageRank | References | Authors |
0.34 | 0 | 5 |
Name | Order | Citations | PageRank |
|---|---|---|---|
| Nomin-Erdene Oyunbaatar | 1 | 0 | 0.34 |
| Deok-Hyu Lee | 2 | 0 | 0.34 |
| Swati J. Patil | 3 | 3 | 1.40 |
| Eung-Sam Kim | 4 | 0 | 0.34 |
| Dong-Weon Lee | 5 | 12 | 3.07 |