Name
Title | ||
|---|---|---|
DASE: Condition-specific differential alternative splicing variants estimation method without reference genome sequence, and its application to non-model organisms |
Abstract | ||
|---|---|---|
Alternative splicing is a mechanism to produce gene expression diversity under the constraint of a limited number of genes, causing spatiotemporal gene expression in many tissues and developmental processes in organisms. This mechanism is well studied in model organisms but not in non-model organisms because the current standard method requires genomic sequences as well as fully annotated information of exons and introns, that are not accessible from non-model organisms. However, it is essential to uncover the landscape of alternative splicing of organisms to understand its evolutionary impacts and roles. We developed a method for condition-specific alternative splicing estimation based on de novo transcriptome assembly, and it would help to enlarge knowledge of alternative splicing functionalized in non-model organisms. The software is deposited to https://github.com/koukiyonezawa/DASE. |
Year | DOI | Venue |
|---|---|---|
2016 | 10.1109/BIBM.2016.7822540 | 2016 IEEE International Conference on Bioinformatics and Biomedicine (BIBM) |
Keywords | Field | DocType |
RNA-seq,isoforms,expression diversity | De novo transcriptome assembly,Spatiotemporal gene expression,Gene,Biology,Exon,Alternative splicing,Genomics,RNA splicing,Bioinformatics,Genetics,Reference genome | Conference |
ISBN | Citations | PageRank |
978-1-5090-1612-9 | 0 | 0.34 |
References | Authors | |
5 | 4 | |
Name | Order | Citations | PageRank |
|---|---|---|---|
| Kouki Yonezawa | 1 | 17 | 4.05 |
| Tsukasa Mori | 2 | 0 | 0.34 |
| Shu-ichi Shigeno | 3 | 0 | 0.34 |
| Atsushi Ogura | 4 | 0 | 1.35 |