Name
Title | ||
|---|---|---|
Learning schizophrenia imaging genetics data via Multiple Kernel Canonical Correlation Analysis |
Abstract | ||
|---|---|---|
Kernel and Multiple Kernel Canonical Correlation Analysis (CCA) are employed to classify schizophrenic and healthy patients based on their SNPs, DNA Methylation and fMRI data. Kernel and Multiple Kernel CCA are popular methods for finding nonlinear correlations between high-dimensional datasets. Data was gathered from 183 patients, 79 with schizophrenia and 104 healthy controls. Kernel and Multiple Kernel CCA represent new avenues for studying schizophrenia, because, to our knowledge, these methods have not been used on these data before. Classification is performed via k nearest neighbors on the kernel matrix outputs of the Kernel and Multiple Kernel CCA algorithm. Accuracies of the Kernel and Multiple Kernel CCA classification are compared to that of the regularized linear CCA algorithm classification, and are found to be significantly more accurate. Both algorithms demonstrate maximal accuracies when the combination of DNA methylation and fMRI data are used, and experience lower accuracies when the SNP data are incorporated. |
Year | DOI | Venue |
|---|---|---|
2016 | 10.1109/BIBM.2016.7822570 | 2016 IEEE International Conference on Bioinformatics and Biomedicine (BIBM) |
Keywords | Field | DocType |
learning schizophrenia imaging genetics data,multiple kernel canonical correlation analysis,schizophrenic patient classification,healthy patient classification,DNA methylation,fMRI data,k nearest neighbors,regularized linear CCA algorithm classification | Kernel (linear algebra),Principal component regression,Pattern recognition,Radial basis function kernel,Kernel Fisher discriminant analysis,Kernel principal component analysis,Polynomial kernel,Artificial intelligence,Kernel method,Mathematics,Machine learning,Kernel (statistics) | Conference |
ISSN | ISBN | Citations |
2156-1125 | 978-1-5090-1612-9 | 0 |
PageRank | References | Authors |
0.34 | 12 | 4 |
Name | Order | Citations | PageRank |
|---|---|---|---|
| Owen Richfield | 1 | 0 | 0.34 |
| Md. Ashad Alam | 2 | 10 | 2.91 |
| Vince D Calhoun | 3 | 2769 | 268.91 |
| Yu-Ping Wang | 4 | 281 | 58.87 |