Abstract | ||
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Resting state functional magnetic resonance imaging (rsfMRI) has emerged as a versatile tool for non-invasive measurement of functional connectivity patterns in the brain. RsfMRI brain dynamics in rodents, non-human primates, and humans share similar properties; however, little is known about the resting state functional connectivity patterns in the ferret, an animal model with high potential for developmental and cognitive translational study. To address this knowledge-gap, we performed rsfMRI on anesthetized ferrets using a 9.4T MRI scanner, and subsequently performed group-level independent component analysis (gICA) to identify functionally connected brain networks. Group-level ICA analysis revealed distributed sensory, motor, and higher-order networks in the ferret brain. Subsequent connectivity analysis showed interconnected higher-order networks that constituted a putative default mode network (DMN), a network that exhibits altered connectivity in neuropsychiatric disorders. Finally, we assessed ferret brain topological efficiency using graph theory analysis and found that the ferret brain exhibits small-world properties. Overall, these results provide additional evidence for pan-species resting-state networks, further supporting ferret-based studies of sensory and cognitive function. |
Year | DOI | Venue |
---|---|---|
2016 | 10.1016/j.neuroimage.2016.09.003 | NeuroImage |
Keywords | Field | DocType |
Resting state,fMRI,Ferret,Default mode network,Networks,Graph theory | Default mode network,Neuroscience,Functional magnetic resonance imaging,Resting state fMRI,Psychology,Network topology,Cognition,Sensory system,Animal model | Journal |
Volume | ISSN | Citations |
143 | 1053-8119 | 1 |
PageRank | References | Authors |
0.36 | 0 | 9 |
Name | Order | Citations | PageRank |
---|---|---|---|
Zhe Charles Zhou | 1 | 1 | 0.36 |
Andrew P. Salzwedel | 2 | 24 | 1.76 |
Susanne Radtke-Schuller | 3 | 1 | 0.36 |
Yuhui Li | 4 | 1 | 0.36 |
Kristin K. Sellers | 5 | 5 | 1.21 |
John H Gilmore | 6 | 843 | 59.79 |
Yen-Yu I. Shih | 7 | 35 | 5.06 |
Flavio Fröhlich | 8 | 9 | 2.62 |
Wei Gao | 9 | 91 | 7.05 |