Paper Info
Title
The BOLD cerebrovascular reactivity response to progressive hypercapnia in young and elderly.
Abstract
Blood Oxygenation Level Dependent (BOLD) imaging in combination with vasoactive stimuli can be used to probe cerebrovascular reactivity (CVR). Characterizing the healthy, age-related changes in the BOLD-CVR response can provide a reference point from which to distinguish abnormal CVR from the otherwise normal effects of ageing. Using a computer controlled gas delivery system, we examine differences in BOLD-CVR response to progressive hypercapnia between 16 young (28±3years, 9 female) and 30 elderly subjects (66±4years, 13 female). Furthermore, we incorporate baseline T2* information to broaden our interpretation of the BOLD-CVR response. Significant age-related differences were observed. Grey matter CVR at 7mmHg above resting PetCO2 was lower amongst elderly (0.19±0.06%ΔBOLD/mmHg) as compared to young subjects (0.26±0.07%ΔBOLD/mmHg). White matter CVR at 7mmHg above baseline PetCO2 showed no significant difference between young (0.04±0.02%ΔBOLD/mmHg) and elderly subjects (0.05±0.03%ΔBOLD/mmHg). We saw no significant differences in the BOLD signal response to progressive hypercapnia between male and female subjects in either grey or white matter. The observed differences in the healthy BOLD-CVR response could be explained by age-related changes in vascular mechanical properties.
Year
DOI
Venue
2016
10.1016/j.neuroimage.2016.06.010
NeuroImage
Field
DocType
Volume
Developmental psychology,Ageing,Grey matter,White matter,Internal medicine,Cardiology,Psychology,Hypercapnia,Blood oxygenation level dependent,Delivery system,Vasoactive,Endocrinology
Journal
139
ISSN
Citations 
PageRank 
1053-8119
0
0.34
References 
Authors
0
8
Name
Order
Citations
PageRank
Alex A. Bhogal1292.89
Jill B. De Vis200.34
Jeroen C. W. Siero3575.09
Esben T Petersen420.75
Peter R. Luijten5464.33
Jeroen Hendrikse6165.00
Marielle E. P. Philippens700.34
Hans Hoogduin800.34